| 08/19/2021 | vs Wisconsin | L | 0-4 | 0-1-0, 0-0-0 | 0-0-0 | 241 | Â |
| 08/22/2021 | vs Missouri St. | W | 2-1 | 1-1-0, 0-0-0 | 0-0-0 | 377 | Meghan White (1) (Bela Gonzalez , Sophia Limongi)
Kassi Ginther (1) (Morgan McLaughlin , Rileigh Kuhns)
|
| 08/27/2021 | at Southern Ill. | W | 3-2 | 2-1-0, 0-0-0 | 0-0-0 | 250 | Kassi Ginther (3) (Morgan McLaughlin)
Kassi Ginther (3) (Lillie Fields)
Rileigh Kuhns (1) (Gabrielle Simms)
|
| 08/29/2021 | at SIUE | L | 1-2 | 2-2-0, 0-0-0 | 0-0-0 | 164 | Anna Jennings (1) (Rileigh Kuhns)
|
| 09/03/2021 | at Oklahoma | L | 1-2 | 2-3-0, 0-0-0 | 0-0-0 | 268 | Kassi Ginther (4) (Emma Byrne)
|
| 09/05/2021 | at Tulsa | L | 1-5 | 2-4-0, 0-0-0 | 0-0-0 | 178 | Sophia Limongi (1)
|
| 09/09/2021 | vs Iowa | L | 0-2 | 2-5-0, 0-0-0 | 0-0-0 | 262 | Â |
| 09/12/2021 | vs Creighton | L | 0-3 | 2-6-0, 0-0-0 | 0-0-0 | 196 | Â |
| 09/17/2021 | at Drake | L | 0-2 | 2-7-0, 0-0-0 | 0-0-0 | 213 | Â |
| 09/19/2021 | at UNI | L | 0-2 | 2-8-0, 0-0-0 | 0-0-0 | 0 | Â |
| 10/01/2021 | at North Dakota | W | 1-0 | 3-8-0, 1-0-0 | 1-0-0 | 17 | Emma Wilson (1) (Anna Jennings)
|
| 10/03/2021 | at North Dakota St. | W | 1-0 | 4-8-0, 2-0-0 | 2-0-0 | 201 | Emma Wilson (2) (Emily Jensen , Kassi Ginther)
|
| 10/08/2021 | vs South Dakota St. | L | 0-1 | 4-9-0, 2-1-0 | 2-1-0 | 242 | Â |
| 10/10/2021 | vs South Dakota | L | 0-1 | 4-10-0, 2-2-0 | 2-2-0 | 150 | Â |
| 10/15/2021 | at Denver | L | 1-6 | 4-11-0, 2-3-0 | 2-3-0 | 520 | Emily Jensen (1) (Gabrielle Simms)
|
| 10/17/2021 | at Omaha | W | 2-1 | 5-11-0, 3-3-0 | 3-3-0 | 147 | Kassi Ginther (5)
Sarah Karloff (1) (Morgan McLaughlin , Lillie Fields)
|
| 10/22/2021 | vs Western Ill. | L | 0-1 | 5-12-0, 3-4-0 | 3-4-0 | 169 | Â |
| 10/24/2021 | vs St. Thomas (MN) | W | 2-1 | 6-12-0, 4-4-0 | 4-4-0 | 127 | Kassi Ginther (6) (Sophia Limongi)
Morgan McLaughlin (1)
|
| 10/31/2021 | vs Oral Roberts | L | 1-2 | 6-13-0, 4-5-0 | 4-5-0 | 182 | Emily Jensen (2) (Bela Gonzalez , Sarah Karloff)
|
